Located in Central and Northeast Africa, where they roost and nest on steep cliff faces, the Rüppell's has no vocal chords. Despite this, it can make a variety of sounds, including screeches and hisses, usually when angry or when fighting over food. In some regions, it is the dominant vulture at a feeding site, though in other areas it is often out-bullied by the larger Lappet-Faced Vulture.
Rüppell's Griffons begin their search for food two hours after sunrise, soaring for hours on end, searching for the carcasses of large animals with their keen eyesight. Although they mostly feed on carrion, they will sometimes kill young antelope and catch snakes, large insects or lizards.